BioInnovatise citations
Contributing to discovery in precision medicine
Since our founding, we have been thrilled to contribute to the exciting and rapidly changing scientific community. Our services have been used in various field applications and across the spectrum of organizations from academic labs to large pharmaceutical companies.
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Mutagenesis
A Novel STAT1 Mutation Associated with Disseminated Mycobacterial Disease
2012 | Plasmid STAT1 construct | doi.org/10.1007/s10875-012-9659-2 | Journal of Clinical Immunology
Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter
2014 | Plasmid construct | doi.org/10.1016/j.jbiotec.2014.08.033 | Journal of Biotechnology
Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis
2013 | Plasmid STAT1 construct | doi.org/10.1016/j.jaci.2013.01.052 | Journal of Allergy and Clinical Immunology
Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor
2021 | Plasmid gRNA construct | doi.org/10.1124/molpharm.121.000336 | Molecular Pharmacology
Novel signal transducer and activator of transcription 1 mutation disrupts small ubiquitin-related modifier conjugation causing gain of function
2018 | Plasmid STAT1 construct | doi.org/10.1016/j.jaci.2017.07.027 | Journal of Allergy and Clinical Immunology
Progressive Multifocal Leukoencephalopathy in Primary Immune Deficiencies: Stat1 Gain of Function and Review of the Literature
2016 | Plasmid construct | Plasmid STAT1 construct | doi.org/10.1093/cid/civ1220 | Clinical Infectious Diseases
SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor Growth
2017 | Plasmid construct | doi.org/10.1158/0008-5472.CAN-16-2393 | Molecular and Cellular Pathobiology
SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth
2016 | Plasmid construct | doi.org/10.1158/0008-5472.CAN-15-2498 | Molecular and Cellular Pathobiology
SIRT1 Deacetylates FOXA2 and Is Critical for Pdx1 Transcription and β-Cell Formation
2013 | Plasmid construct | doi.org/10.7150%2Fijbs.7529 | International Journal of Biological Sciences
Repair of UV photolesions in xeroderma pigmentosum group C cells induced by translational readthrough of premature termination codons.
2013 | Plasmid construct | doi.org/10.1073/pnas.1312088110 | Proceedings of the National Academy of Sciences of the United States of America
Improving Treatment of Mycobacterial Infections
2016 | Plasmid STAT1 construct | repub.eur.nl/pub/94589/ | Erasmus University Rotterdam Department of Internal Medicine
MicroRNA-30 inhibits antiapoptotic factor Mcl-1 in mouse and human hematopoietic cells after radiation exposure
2016 | Plasmid construct | doi.org/10.1007/s10495-016-1238-1 | Apoptosis
Direct interaction of eag domains and cyclic nucleotide–binding homology domains regulate deactivation gating in hERG channels
2013 | Plasmid construct | doi.org/10.1085/jgp.201310995 | Journal of General Physiology
Novel Stat1 Mutation Disrupts Small Ubiquitin-related Modifier (Sumo) Conjugation Causing Gain of Function
2017 | Plasmid construct | doi.org/10.1016/j.jaci.2017.07.027 | Journal of Allergy and Clinical Immunology
Effects of Single Nucleotide Polymorphisms in Human KCNMA1 on BK Current Properties
2019 | Plasmid construct | doi.org/10.3389/fnmol.2019.00285 | Frontiers in Molecular Neuroscience
The hERG potassium channel intrinsic ligand regulates N- and C-terminal interactions and channel closure
2019 | Plasmid construct | doi.org/10.1085/jgp.201812129 | Journal of General Physiology
Identification and targeting of novel CDK9 complexes in acute myeloid leukemia
2019 | Plasmid CDK9 construct | doi.org/10.1182/blood-2018-08-870089 | Blood
Unbiased Analysis of the Functions and Interactions of Human Inflammasome Mutations
2021 | Plasmid construct | University of Pittsburgh
Novel Protein Kinase C-Mediated Control of Orai1 Function in Invasive Melanoma
2015 | Plasmid construct | doi.org/10.1128/MCB.01500-14 | Molecular and Cellular Biology
Gp29 LysA of mycobacteriophage TM4 can hydrolyze peptidoglycan through an N-acetyl-muramoyl-L-alanine amidase activity
2022 | Plasmid construct | doi.org/10.1016/j.bbapap.2021.140745 | Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter
2019 | Plasmid construct | doi.org/10.1038/s41467-019-10352-4 | Nature Communications
Lifespan Kras mutation levels in lung and liver of B6C3F1 mice
2018 | Plasmid construct | doi.org/10.1002/em.22198 | Environmental and Molecular Mutagenesis
Structural mapping of patient-associated KCNMA1 gene variants.
2023 | Plasmid construct | doi.org/10.1101/2023.07.27.550850 | bioRxiv
An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
2014 | Plasmid construct | doi.org/10.1038/ng.3089 | Nature Genetics
Evaluation of IRX Genes and Conserved Noncoding Elements in a Region on 5p13.3 Linked to Families with Familial Idiopathic Scoliosis and Kyphosis
2016 | Plasmid construct | doi.org/10.1534/g3.116.029975 | G3 Genes|Genomes|Genetics
Distinct mutations at the same positions of STAT3 cause either loss or gain of function
2016 | Plasmid construct | doi.org/10.1042/BCJ20160572 | Journal of Allergy and Clinical Immunology
HERG eag/PAS (ether-á-go-go/Per-Arnt-Sim) Domain: Elucidating its Role in Regulating Channel Gating in Physiology and Disease.
2012 | Plasmid construct | University of Mary Washington Department of Biology
Effects of heterologous expression of human cyclic nucleotide phosphodiesterase 3A (hPDE3A) on redox regulation in yeast
2016 | Plasmid construct | doi.org/10.1042/BCJ20160572 | Biochemical Journal
Visualizing the phage T4 activated transcription complex of DNA and E. coli RNA polymerase
2016 | Plasmid construct | doi.org/10.1093/nar/gkw656 | Nucleic Acids Research
High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19
2021 | Plasmid construct | doi.org/10.1371/journal.ppat.1009431 | PLOS Pathogens
Architecture of the Bacteriophage T4 Activator MotA/Promoter DNA Interaction during Sigma Appropriation*
2013 | Plasmid construct | doi.org/10.1074/jbc.M113.475434 | Journal of Biological Chemistry
The N-linker region of hERG1a upregulates hERG1b potassium channels
2022 | Plasmid construct | doi.org/10.1016/j.jbc.2022.102233 | Journal of Biological Chemistry
Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms
2022 | Plasmid construct | doi.org/10.1038/s41467-022-29381-7 | Nature Communications
Molecular Modeling Predicts Novel Antibody Escape Mutations in the Respiratory Syncytial Virus Fusion Glycoprotein
2022 | Plasmid construct | doi.org/10.1128/jvi.00353-22 | Journal of Virology
Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D 3 Dopamine Receptor
2020 | Plasmid construct | doi.org/10.1021/acschemneuro.0c00425 | American Chemical Society Chemical Neuroscience
Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging
2016 | Plasmid construct | doi.org/10.1038/srep28633 | Scientific Reports
A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity
2020 | Plasmid construct | doi.org/10.1126/scisignal.aaw5885 | Science Signaling
Delineation of G Protein-Coupled Receptor Kinase Phosphorylation Sites within the D1 Dopamine Receptor and Their Roles in Modulating β-Arrestin Binding and Activation
2023 | Plasmid construct | doi.org/10.3390/ijms24076599 | International Journal of Molecular Sciences
Identification and Characterization of ML321: A Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity
2022 | Plasmid construct | doi.org/10.1021/acsptsci.2c00202 | ACS Pharmacology & Translational Science
Ppt1-deficiency dysregulates lysosomal Ca++ homeostasis contributing to pathogenesis in a mouse model of CLN1 disease
2022 | Plasmid construct | doi.org/10.1002/jimd.12485 | Journal of Inherited Metabolic Disease
R-type voltage-gated Ca2+ channels mediate A-type K+ current regulation of synaptic input in hippocampal dendrites
2022 | Plasmid construct | doi.org/10.1016/j.celrep.2021.110264 | Cell Reports
Characterization of Phytohormones from Botanical Supplements for Steroid Hormone Receptor Activity
2021 | Plasmid construct | University of Arkansas
Aberrant Acetylation of Mitochondrial Proteins, due to Loss of SIRT3, Results in Tumor Permissive Phenotypes and Increases Breast Cancer Malignancy Risk
2017 | Plasmid construct | Northwestern University
Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist
2020 | Plasmid construct | doi.org/10.1021/acs.jmedchem.0c00424 | Journal of Medicinal Chemistry
Second-site suppressor mutations reveal connection between the drug-binding pocket and nucleotide-binding domain 1 of human P-glycoprotein (ABCB1)
2023 | Plasmid construct | doi.org/10.1016/j.drup.2023.101009 | Drug Resistance Updates
A polybasic motif in alternatively spliced KChIP2 isoforms prevents Ca2+ regulation of Kv4 channels
2019 | Plasmid construct | doi.org/10.1074/jbc.RA118.006549 | Journal of Biological Chemistry
Characterization of a Mutant RNA Polymerase in Bacteriophage T4 Prereplicative Transcription
2013 | Plasmid construct | New York University Department of Basic Medical Science
Functional Characterization of MnSod and ACSS1 Acetylation in Metabolism and Carcinogenesis
2021 | Plasmid construct | Northwestern University
Mechanisms of Diurnal Regulation of the BK current in the Brain’s Central Clock
2016 | Plasmid construct | University of Maryland School of Medicine
Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model
2017 | Plasmid construct | doi.org/10.1038/ncomms14612 | Nature Communications
Intégration du VIH-1 : Contrôle et régulation de l’interaction fonctionnelle entre l’intégrase et la chromatine
2016 | Plasmid construct | Université de Bordeaux
miR-124-3p Regulates FGF2–EGFR Pathway to Overcome Pemetrexed Resistance in Lung Adenocarcinoma Cells by Targeting MGAT5
2023 | Pc9 | doi.org/10.2147/CMAR.S274192 | Cancer Management and Research
Recombinant Proteins
Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2
2016 | Plasmid construct | doi.org/10.1021/acschembio.5b01047 | American Chemical Biology
Viral Packaging
MnSOD Lysine 68 acetylation leads to cisplatin and doxorubicin resistance due to aberrant mitochondrial metabolism
2021 | Lentivirus | doi.org/10.7150/ijbs.51184 | International Journal of Biologics Sciences
Structure-based classification predicts drug response in EGFR-mutant NSCLC
2021 | Retrovirus | doi.org/10.1038/s41586-021-03898-1 | Nature
Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer
2018 | Retrovirus | doi.org/10.1038/s41591-018-0007-9 | Nature Medicine
Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity
2019 | Retrovirus | doi.org/10.1016/j.ccell.2019.09.001 | Cancer Cell