Research Citations

Contributing to Discovery in Precision Medicine

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Mutagenesis and Molecular Cloning

Discovery of Transcription Factors Involved in the Maintenance of Resident Vascular Endothelial Stem Cell Properties

2024 | Plasmid construct | | Molecular and Cellular Biology

Clinical and functional spectrum of RAC2-related immunodeficiency

2024 | Plasmid construct | | Blood

Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease

2024 | Plasmid Lamtor1 construct | | Journal of Biological Chemistry

Photo-crosslinking hERG channels causes a U.V.-driven, state-dependent disruption of kinetics and voltage dependence of activation

2024 | Plasmid ERG construct | | bioRxiv

A Novel STAT1 Mutation Associated with Disseminated Mycobacterial Disease

2012 | Plasmid STAT1 construct | | Journal of Clinical Immunology

Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter

2014 | Plasmid construct | | Journal of Biotechnology

Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis

2013 | Plasmid STAT1 construct | | Journal of Allergy and Clinical Immunology

Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor

2021 | Plasmid gRNA construct | | Molecular Pharmacology

Novel signal transducer and activator of transcription 1 mutation disrupts small ubiquitin-related modifier conjugation causing gain of function

2018 | Plasmid STAT1 construct | | Journal of Allergy and Clinical Immunology

Progressive Multifocal Leukoencephalopathy in Primary Immune Deficiencies: Stat1 Gain of Function and Review of the Literature

2016 | Plasmid construct | Plasmid STAT1 construct | | Clinical Infectious Diseases

SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor Growth

2017 | Plasmid construct | | Molecular and Cellular Pathobiology

SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth

2016 | Plasmid construct | | Molecular and Cellular Pathobiology

SIRT1 Deacetylates FOXA2 and Is Critical for Pdx1 Transcription and β-Cell Formation

2013 | Plasmid construct | | International Journal of Biological Sciences

Repair of UV photolesions in xeroderma pigmentosum group C cells induced by translational readthrough of premature termination codons.

2013 | Plasmid construct | | Proceedings of the National Academy of Sciences of the United States of America

Improving Treatment of Mycobacterial Infections

2016 | Plasmid STAT1 construct | | Erasmus University Rotterdam Department of Internal Medicine

MicroRNA-30 inhibits antiapoptotic factor Mcl-1 in mouse and human hematopoietic cells after radiation exposure

2016 | Plasmid construct | | Apoptosis

Direct interaction of eag domains and cyclic nucleotide–binding homology domains regulate deactivation gating in hERG channels

2013 | Plasmid construct | | Journal of General Physiology

Novel Stat1 Mutation Disrupts Small Ubiquitin-related Modifier (Sumo) Conjugation Causing Gain of Function

2017 | Plasmid construct | | Journal of Allergy and Clinical Immunology

Effects of Single Nucleotide Polymorphisms in Human KCNMA1 on BK Current Properties

2019 | Plasmid construct | | Frontiers in Molecular Neuroscience

The hERG potassium channel intrinsic ligand regulates N- and C-terminal interactions and channel closure

2019 | Plasmid construct | | Journal of General Physiology

Identification and targeting of novel CDK9 complexes in acute myeloid leukemia

2019 | Plasmid CDK9 construct | | Blood

Unbiased Analysis of the Functions and Interactions of Human Inflammasome Mutations

2021 | Plasmid construct | University of Pittsburgh

Novel Protein Kinase C-Mediated Control of Orai1 Function in Invasive Melanoma

2015 | Plasmid construct | | Molecular and Cellular Biology

Gp29 LysA of mycobacteriophage TM4 can hydrolyze peptidoglycan through an N-acetyl-muramoyl-L-alanine amidase activity

2022 | Plasmid construct | | Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics

Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

2019 | Plasmid construct | | Nature Communications

Lifespan Kras mutation levels in lung and liver of B6C3F1 mice

2018 | Plasmid construct | | Environmental and Molecular Mutagenesis

Structural mapping of patient-associated KCNMA1 gene variants.

2023 | Plasmid construct | | bioRxiv

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

2014 | Plasmid construct | | Nature Genetics

Evaluation of IRX Genes and Conserved Noncoding Elements in a Region on 5p13.3 Linked to Families with Familial Idiopathic Scoliosis and Kyphosis

2016 | Plasmid construct | | G3 Genes|Genomes|Genetics

Distinct mutations at the same positions of STAT3 cause either loss or gain of function

2016 | Plasmid construct | | Journal of Allergy and Clinical Immunology

HERG eag/PAS (ether-á-go-go/Per-Arnt-Sim) Domain: Elucidating its Role in Regulating Channel Gating in Physiology and Disease.

2012 | Plasmid construct | University of Mary Washington Department of Biology

Effects of heterologous expression of human cyclic nucleotide phosphodiesterase 3A (hPDE3A) on redox regulation in yeast

2016 | Plasmid construct | | Biochemical Journal

Visualizing the phage T4 activated transcription complex of DNA and E. coli RNA polymerase

2016 | Plasmid construct | | Nucleic Acids Research

High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19

2021 | Plasmid construct | | PLOS Pathogens

Architecture of the Bacteriophage T4 Activator MotA/Promoter DNA Interaction during Sigma Appropriation*

2013 | Plasmid construct | | Journal of Biological Chemistry

The N-linker region of hERG1a upregulates hERG1b potassium channels

2022 | Plasmid construct | | Journal of Biological Chemistry

Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms

2022 | Plasmid construct | | Nature Communications

Molecular Modeling Predicts Novel Antibody Escape Mutations in the Respiratory Syncytial Virus Fusion Glycoprotein

2022 | Plasmid construct | | Journal of Virology

Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D 3 Dopamine Receptor

2020 | Plasmid construct | | American Chemical Society Chemical Neuroscience

Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging

2016 | Plasmid construct | | Scientific Reports

A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity

2020 | Plasmid construct | | Science Signaling

Delineation of G Protein-Coupled Receptor Kinase Phosphorylation Sites within the D1 Dopamine Receptor and Their Roles in Modulating β-Arrestin Binding and Activation

2023 | Plasmid construct | | International Journal of Molecular Sciences

Identification and Characterization of ML321: A Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity

2022 | Plasmid construct | | ACS Pharmacology & Translational Science

Ppt1-deficiency dysregulates lysosomal Ca++ homeostasis contributing to pathogenesis in a mouse model of CLN1 disease

2022 | Plasmid construct | | Journal of Inherited Metabolic Disease

R-type voltage-gated Ca2+ channels mediate A-type K+ current regulation of synaptic input in hippocampal dendrites

2022 | Plasmid construct | | Cell Reports

Characterization of Phytohormones from Botanical Supplements for Steroid Hormone Receptor Activity

2021 | Plasmid construct | University of Arkansas

Aberrant Acetylation of Mitochondrial Proteins, due to Loss of SIRT3, Results in Tumor Permissive Phenotypes and Increases Breast Cancer Malignancy Risk

2017 | Plasmid construct | Northwestern University

Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist

2020 | Plasmid construct | | Journal of Medicinal Chemistry

Second-site suppressor mutations reveal connection between the drug-binding pocket and nucleotide-binding domain 1 of human P-glycoprotein (ABCB1)

2023 | Plasmid construct | | Drug Resistance Updates

A polybasic motif in alternatively spliced KChIP2 isoforms prevents Ca2+ regulation of Kv4 channels

2019 | Plasmid construct | | Journal of Biological Chemistry

Characterization of a Mutant RNA Polymerase in Bacteriophage T4 Prereplicative Transcription

2013 | Plasmid construct | New York University Department of Basic Medical Science

Functional Characterization of MnSod and ACSS1 Acetylation in Metabolism and Carcinogenesis

2021 | Plasmid construct | Northwestern University

Mechanisms of Diurnal Regulation of the BK current in the Brain’s Central Clock

2016 | Plasmid construct | University of Maryland School of Medicine

Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

2017 | Plasmid construct | | Nature Communications

Intégration du VIH-1 : Contrôle et régulation de l’interaction fonctionnelle entre l’intégrase et la chromatine

2016 | Plasmid construct | Université de Bordeaux

miR-124-3p Regulates FGF2–EGFR Pathway to Overcome Pemetrexed Resistance in Lung Adenocarcinoma Cells by Targeting MGAT5

2023 | Pc9 | | Cancer Management and Research

Recombinant Proteins

Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2

2016 | Plasmid construct | | American Chemical Biology

Viral Packaging

MnSOD Lysine 68 acetylation leads to cisplatin and doxorubicin resistance due to aberrant mitochondrial metabolism

2021 | Lentivirus | | International Journal of Biologics Sciences

Structure-based classification predicts drug response in EGFR-mutant NSCLC

2021 | Retrovirus | | Nature

Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer

2018 | Retrovirus | | Nature Medicine

Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity

2019 | Retrovirus | | Cancer Cell