BioInnovatise citations

Contributing to discovery in precision medicine

Since our founding, we have been thrilled to contribute to the exciting and rapidly changing scientific community. Our services have been used in various field applications and across the spectrum of organizations from academic labs to large pharmaceutical companies. 

Is your research missing? Contact our team at to get listed below. 


A Novel STAT1 Mutation Associated with Disseminated Mycobacterial Disease

2012 | Plasmid STAT1 construct | | Journal of Clinical Immunology


Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter

2014 | Plasmid construct | | Journal of Biotechnology


Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis

2013 | Plasmid STAT1 construct | | Journal of Allergy and Clinical Immunology


Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor

2021 | Plasmid gRNA construct | | Molecular Pharmacology


Novel signal transducer and activator of transcription 1 mutation disrupts small ubiquitin-related modifier conjugation causing gain of function

2018 | Plasmid STAT1 construct | | Journal of Allergy and Clinical Immunology


Progressive Multifocal Leukoencephalopathy in Primary Immune Deficiencies: Stat1 Gain of Function and Review of the Literature

2016 | Plasmid construct | Plasmid STAT1 construct | | Clinical Infectious Diseases


SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor Growth

2017 | Plasmid construct | | Molecular and Cellular Pathobiology


SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth

2016 | Plasmid construct | | Molecular and Cellular Pathobiology


SIRT1 Deacetylates FOXA2 and Is Critical for Pdx1 Transcription and β-Cell Formation

2013 | Plasmid construct | | International Journal of Biological Sciences


Repair of UV photolesions in xeroderma pigmentosum group C cells induced by translational readthrough of premature termination codons.

2013 | Plasmid construct | | Proceedings of the National Academy of Sciences of the United States of America


Improving Treatment of Mycobacterial Infections

2016 | Plasmid STAT1 construct | | Erasmus University Rotterdam Department of Internal Medicine


MicroRNA-30 inhibits antiapoptotic factor Mcl-1 in mouse and human hematopoietic cells after radiation exposure

2016 | Plasmid construct | | Apoptosis


Direct interaction of eag domains and cyclic nucleotide–binding homology domains regulate deactivation gating in hERG channels

2013 | Plasmid construct | | Journal of General Physiology


Novel Stat1 Mutation Disrupts Small Ubiquitin-related Modifier (Sumo) Conjugation Causing Gain of Function

2017 | Plasmid construct | | Journal of Allergy and Clinical Immunology


Effects of Single Nucleotide Polymorphisms in Human KCNMA1 on BK Current Properties

2019 | Plasmid construct | | Frontiers in Molecular Neuroscience


The hERG potassium channel intrinsic ligand regulates N- and C-terminal interactions and channel closure

2019 | Plasmid construct | | Journal of General Physiology


Identification and targeting of novel CDK9 complexes in acute myeloid leukemia

2019 | Plasmid CDK9 construct | | Blood


Unbiased Analysis of the Functions and Interactions of Human Inflammasome Mutations

2021 | Plasmid construct | University of Pittsburgh


Novel Protein Kinase C-Mediated Control of Orai1 Function in Invasive Melanoma

2015 | Plasmid construct | | Molecular and Cellular Biology


Gp29 LysA of mycobacteriophage TM4 can hydrolyze peptidoglycan through an N-acetyl-muramoyl-L-alanine amidase activity

2022 | Plasmid construct | | Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics


Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

2019 | Plasmid construct | | Nature Communications


Lifespan Kras mutation levels in lung and liver of B6C3F1 mice

2018 | Plasmid construct | | Environmental and Molecular Mutagenesis


Structural mapping of patient-associated KCNMA1 gene variants.

2023 | Plasmid construct | | bioRxiv


An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

2014 | Plasmid construct | | Nature Genetics


Evaluation of IRX Genes and Conserved Noncoding Elements in a Region on 5p13.3 Linked to Families with Familial Idiopathic Scoliosis and Kyphosis

2016 | Plasmid construct | | G3 Genes|Genomes|Genetics


Distinct mutations at the same positions of STAT3 cause either loss or gain of function

2016 | Plasmid construct | | Journal of Allergy and Clinical Immunology


HERG eag/PAS (ether-á-go-go/Per-Arnt-Sim) Domain: Elucidating its Role in Regulating Channel Gating in Physiology and Disease.

2012 | Plasmid construct | University of Mary Washington Department of Biology


Effects of heterologous expression of human cyclic nucleotide phosphodiesterase 3A (hPDE3A) on redox regulation in yeast

2016 | Plasmid construct | | Biochemical Journal


Visualizing the phage T4 activated transcription complex of DNA and E. coli RNA polymerase

2016 | Plasmid construct | | Nucleic Acids Research


High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19

2021 | Plasmid construct | | PLOS Pathogens


Architecture of the Bacteriophage T4 Activator MotA/Promoter DNA Interaction during Sigma Appropriation*

2013 | Plasmid construct | | Journal of Biological Chemistry


The N-linker region of hERG1a upregulates hERG1b potassium channels

2022 | Plasmid construct | | Journal of Biological Chemistry


Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms

2022 | Plasmid construct | | Nature Communications


Molecular Modeling Predicts Novel Antibody Escape Mutations in the Respiratory Syncytial Virus Fusion Glycoprotein

2022 | Plasmid construct | | Journal of Virology


Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D 3 Dopamine Receptor

2020 | Plasmid construct | | American Chemical Society Chemical Neuroscience


Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging

2016 | Plasmid construct | | Scientific Reports


A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity

2020 | Plasmid construct | | Science Signaling


Delineation of G Protein-Coupled Receptor Kinase Phosphorylation Sites within the D1 Dopamine Receptor and Their Roles in Modulating β-Arrestin Binding and Activation

2023 | Plasmid construct | | International Journal of Molecular Sciences


Identification and Characterization of ML321: A Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity

2022 | Plasmid construct | | ACS Pharmacology & Translational Science


Ppt1-deficiency dysregulates lysosomal Ca++ homeostasis contributing to pathogenesis in a mouse model of CLN1 disease

2022 | Plasmid construct | | Journal of Inherited Metabolic Disease


R-type voltage-gated Ca2+ channels mediate A-type K+ current regulation of synaptic input in hippocampal dendrites

2022 | Plasmid construct | | Cell Reports


Characterization of Phytohormones from Botanical Supplements for Steroid Hormone Receptor Activity

2021 | Plasmid construct | University of Arkansas


Aberrant Acetylation of Mitochondrial Proteins, due to Loss of SIRT3, Results in Tumor Permissive Phenotypes and Increases Breast Cancer Malignancy Risk

2017 | Plasmid construct | Northwestern University


Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist

2020 | Plasmid construct | | Journal of Medicinal Chemistry


Second-site suppressor mutations reveal connection between the drug-binding pocket and nucleotide-binding domain 1 of human P-glycoprotein (ABCB1)

2023 | Plasmid construct | | Drug Resistance Updates


A polybasic motif in alternatively spliced KChIP2 isoforms prevents Ca2+ regulation of Kv4 channels

2019 | Plasmid construct | | Journal of Biological Chemistry


Characterization of a Mutant RNA Polymerase in Bacteriophage T4 Prereplicative Transcription

2013 | Plasmid construct | New York University Department of Basic Medical Science


Functional Characterization of MnSod and ACSS1 Acetylation in Metabolism and Carcinogenesis

2021 | Plasmid construct | Northwestern University


Mechanisms of Diurnal Regulation of the BK current in the Brain’s Central Clock

2016 | Plasmid construct | University of Maryland School of Medicine


Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

2017 | Plasmid construct | | Nature Communications


Intégration du VIH-1 : Contrôle et régulation de l’interaction fonctionnelle entre l’intégrase et la chromatine

2016 | Plasmid construct | Université de Bordeaux


miR-124-3p Regulates FGF2–EGFR Pathway to Overcome Pemetrexed Resistance in Lung Adenocarcinoma Cells by Targeting MGAT5

2023 | Pc9 | | Cancer Management and Research


Recombinant Proteins

Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2

2016 | Plasmid construct | | American Chemical Biology


Viral Packaging

MnSOD Lysine 68 acetylation leads to cisplatin and doxorubicin resistance due to aberrant mitochondrial metabolism

2021 | Lentivirus | | International Journal of Biologics Sciences


Structure-based classification predicts drug response in EGFR-mutant NSCLC

2021 | Retrovirus | | Nature


Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer

2018 | Retrovirus | | Nature Medicine


Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity

2019 | Retrovirus | | Cancer Cell

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